There is a story, which is completely apocryphal, about former New York Yankee first baseman Wally Pipp. Pipp was a star for the greatest dynasty in baseball history, a sidekick to Babe Ruth, but one day he complained to his manager about a migraine headache. Pipp was benched and in his place, Lou Gehrig was inserted into the line up. Gehrig never missed another game until he contracted a disease so bad they named it after him.
You probably won't be donating to the "Jed Castles Disease Foundation."